No evidence exists to prove that having high levels of bad cholesterol causes heart disease, leading physicians have claimed.
Researchers have warned statins – cholesterol-busting drugs – offer no protection to millions of people and doctors should ‘abandon’ them.
The findings add fuel to the ever-growing, controversial row over statins, as cardiologists continue to disagree on whether the cheap pills have any benefit.
Experts do agree that for people who already have a high heart risk – particularly those who have already had a heart attack or a stroke – statins are proven lifesavers, slashing the chance of a second attack.
High levels of LDL-C, known as bad cholesterol, has been considered a major cause of heart disease – the world’s leading killer – for at least 50 years.
But the new study, based on data of around 1.3 million patients, suggests doling out statins as a main form of treatment for heart disease is of ‘doubtful benefit’.
A team of 17 physicians from across the world discovered high LDL-C levels were unrelated to a higher risk of heart disease in the general population.
This also remained true for patients with familial hypercholesterolemia (FH), a genetic condition that causes them to have abnormal levels of LDL-C.
The study, published in the Expert Review of Clinical Pharmacology, also found no link between high levels of LDL-C and atherosclerosis.
This is despite medical literature stating fatty deposits that clog arteries – known medically as atherosclerosis – are made up of cholesterol.
And heart attack patients were shown to have lower than normal cholesterol levels of LDL-C.
Professor Sherif Sultan, one of the authors, told The Irish Times the ‘strongest finding’ was elderly people with high levels of LDL-C live the longest.
Dr Malcolm Kendrick, a GP who works in Macclesfield and author of The Great Cholesterol Con, was one of the researchers involved.
The remaining scientists, who delved into the data of previous trials, hailed from the US, Ireland, Italy, Sweden, France and Japan.
WHAT IS THE ROW OVER STATINS ABOUT?
Up to six million adults in Britain currently take statins to lower their cholesterol levels and thereby reduce the risk of heart attacks and strokes.
But many doctors and patients are worried about their long-term harms and they have been linked to diabetes, muscular pain and memory loss.
Scores are are uneasy with what they describe as the ‘overmedicalisation’ of the middle-aged, which sees statins doled out ‘just in case’ patients have heart problems in later life.
Supporters on the other hand, including the health watchdog Nice, say the pills should be prescribed more widely to prevent thousands of early deaths.
An array of evidence has already shown statins to be very effective at preventing heart attacks and strokes in patients who have already had one.
Writing in the journal, they wrote: ‘We suggest clinicians should abandon the use of statins and PCSK-9 inhibitors.’
PCSK9 inhibitors are a relatively new class of cholesterol lowering treatments, which studies have shown are just as effective at cutting levels of LDL-C as statins.
Dr Aseem Malhotra, an NHS cardiologist who wasn’t involved in the study, told MailOnline the evidence is mounting against the use of statins.
He said: ‘Having reviewed the totality of the evidence, in my view the only people that should be offered statins are those with established heart disease risk.’
Dr Malhotra, an avid supporter of ditching statins and eating healthily, added that a ‘very small minority of patients’ with FH may also benefit from receiving statins.
He said: ‘For everyone else, the tens of millions taking the drug worldwide who don’t fall into these categories, they should know statins won’t help them live one day longer.’
It comes after a major study in the British Medical Journal concluded last week that giving statins to elderly people in good health could be a waste of time.
The Spanish research of 47,000 over-75s found no evidence that statins make any difference to low-risk patients, despite health officials’ attempts to get more people taking them.
Up to six million adults in Britain currently take statins to lower their cholesterol levels and thereby reduce the risk of heart attacks and strokes.
But many doctors and patients are worried about the pills’ long-term harms and they have been linked to diabetes, muscular pain and memory loss.
Scores are uneasy with what they describe as the ‘overmedicalisation’ of the middle-aged, which sees statins doled out ‘just in case’ patients have heart problems in later life.
Supporters on the other hand, including the health watchdog Nice, say the pills should be prescribed more widely to prevent thousands of early deaths.
An array of evidence has already shown statins to be very effective at preventing heart attacks and strokes in patients who have already had one.
Professor Metin Avkiran, associate medical director at the British Heart Foundation, said: ‘We have more than twenty years’ worth of research showing that statins are an effective way of reducing the risk of a heart attack in people at high risk, particularly those who’ve already suffered a serious cardiovascular event.
‘The opinions expressed in this article don’t change anything, and patients who have been prescribed statins should continue to take them. If you have any concerns you should talk to your doctor.’
END
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